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Rheumatoid arthritis

Rheumatoid arthritis is a chronic inflammatory joint disease.

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Disease pattern

In common parlance, it is often simply said "rheumatism," from the ancient Greek word for flow or river, this because of the flowing pain that moves from joint to joint.

The inner skin of the joints (synovium) is affected, mostly on the hands or feet. The resulting swelling and pain are a great burden to patients. Frequently, destruction of the affected joints can also occur.

Rheumatoid arthritis can develop at any age, but usually begins between 35 and 50. Women may be affected about three times as often as men. A similar clinical picture is also rarely observed in children, juvenile idiopathic arthritis, which, however, has a better prognosis and tends to resolve in adulthood.

The disease can appear very suddenly, but usually it begins insidiously. Usually the symptoms are symmetrical, and joints on both sides of the body are affected similarly.

The affected joints ache and are stiff for about an hour after standing up and after inactivity. They often become sensitive to touch, warm and enlarged, as soft tissue is then swollen and the joint is filled with fluid. The swellings can press on nerves and cause the corresponding discomfort. Joint deformities set in quickly, an joints stiffen so they can no longer be bent and stretched. For example, the hand limbs curve towards the little finger, which can cause finger tendons to slip or become deformed. Mobility becomes massively restricted in some cases.

However, fever, general weakness and fatigue, and damage to other organs may also occur. The course of the disease is characterized by relapses and is progressive; without effective treatment, there can be a complete loss of joint function, which can lead to disability.

Only rarely can rheumatoid arthritis resolve on its own, worsening most severely over about 6 years (especially in the first year of illness). Statistically, it reduces life expectancy by 3 to 7 years.

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Causes

Causes of rheumatoid arthritis

The actual causes of rheumatoid arthritis are unknown. In particular, it is assumed that there is an immune system disorder in the context of an autoimmune disease.

In many patients, certain antibodies are found in the blood, such as rheumatoid factor and anti-CCP antibodies (autoantibodies directed against components of connective tissue).

The latter are detected in more than 75% of patients, whereas they are almost always completely absent in people without rheumatoid arthritis. Likewise, a genetic component is suspected, since familial clusters are observed.

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Therapy

INUSpheresis®  as a successful therapy option for toxicity-related polyneuropathy 

In conventional medicine, therapy is based on symptom suppression, using drugs with side effects (cortisone). The significant clinical efficacy of immunoadsorption has been proven in studies.

Analogous to immune absorption, INUSpheresis®  washes not only rheumatoid antibodies out of the blood but also inflammatory mediators. Thus, it is a promising causal therapy for rheumatoid arthritis.

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