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Nitrosative stress refers to excessive exposure of the organism to oxidized nitrogen radicals.
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Nitrosative stress (nitrosative stress) refers to the body's exposure to nitrogen radicals. These are oxygen compounds containing nitrogen. As free radicals, these oxygen molecules or organic compounds are highly reactive and can impair our health in many ways.
The complaints resulting from nitrosative stress are manifold and often resemble those of other diseases. It can also occur as a concomitant of many chronic diseases. Nitrosative stress is important in chronic fatigue syndrome, fibromyalgia (chronic pain disorder) and numerous autoimmune diseases. It promotes Parkinson's disease and can also trigger cancer by damaging mitochondria (cell organs that provide energy in the cells).
Symptoms observed include refractory pain after trauma to the cervical spine, persistent fatigue, lack of energy, and disruption of thought processes. In general, headaches and other pains or unclear neurological complaints may occur. The appearance of these symptoms after a viral or bacterial infection may be a warning signal of nitrostress.
The syndrome can be detected using a urine test. Degradation products of nitric oxide are determined, for example peroxinitrite. This is formed when nitric oxide reacts with superoxide. Peroxinitrite can trigger a veritable cascade of inflammation within cells, which in turn "fuels" itself by increasing nitric oxide production; this excess production of nitric oxide radicals is a vicious cycle that drives inflammation, which can spread throughout the body. Joint and intestinal problems as well as reduced performance can be a consequence.
Peroxinitrite also stimulates the glutamate receptors in the brain, there is an increased uptake of calcium in neuronal cells. This leads to the swelling of cell bodies, inflammatory processes and increasing cell decay. Peroxidation can also lead to damage to the inside of arteries. Heart attacks and strokes can occur as a result.
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Causes of nitrosative stress
Nitric oxide is a useful substance that is needed in the body for numerous processes. When blood pressure is high, for example, it is released because it dilates the vessels. It is an important messenger substance in the immune system. Many other metabolic processes in our organism require this substance.
However, we must assume that there are adverse health effects if there is an excess of nitrogen radicals in our organism.
Nitrosative stress can be triggered by a variety of causes. Nitrosative stress is observed in the unstable cervical spine with permanent irritation of the spinal cord or also in bacterial/viral inflammations as triggers. Also, great physical strain (heavy exertion with high oxygen consumption) and psychological stress are considered corresponding factors.
In particular, various drugs such as antibiotics, cytostatics or statins are suspected of triggering nitrostess, as is exposure to heavy metals and chemicals and food additives (e.g. due to sprays or fertilizers or stabilizers and emulsifiers in our food).
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INUSpheresis® as support
The preventive effect of INUSpheresis® blood washing, in which environmental toxins and pro-inflammatory molecules are specifically filtered out, is considered an important step towards maintaining a healthy balance concerning nitrogen balance and reducing exposure to nitrogen radicals.
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