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Amyotrophic lateral sclerosis
Environment
Pollution
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In a systematic review and meta-analysis conducted by researchers at Arizona State University, USA, a group of seven environmental factors, including four heavy metals, were shown to increase the risk of amyotrophic lateral sclerosis (ALS).
In ascending order, copper, zinc, mercury, manganese, selenium, formaldehyde, and ß-N-methylamino-L-alanine (BMAA) contribute to ALS. Of these environmental hazards, only BMAA meets Bradford Hill criteria.
The study projects that approximately 22,650 Americans will develop ALS (amyotrophic lateral sclerosis) by 2040, correlating workplace and lifestyle hazards with exposure to environmental toxins. Exposure to toxic environmental chemicals is increased for individuals working in medical occupations, manufacturing, construction, clerical work, and military service.
With respect to BMAA, the chemical at highest risk for developing ALS in susceptible individuals, individuals may consume this toxin in the form of cycad plants or seafood derived from water contaminated with cyanobacteria.
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